Brimonidine tartrate (UK 14304 tartrate)是一种α2-AR激动剂。
|
英文别名 (English Synonym) |
Brimonidine Tartrate |
|
中文名称 (Chinese Name) |
酒石酸溴莫尼定 |
|
靶点 (Target) |
Adrenergic Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
70359-46-5 |
|
分子式 (Formula) |
C15H16BrN5O6 |
|
分子量 (Molecular Weight) |
442.22 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Cambridge D. UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol. 1981 Jul 10,72(4):413-5. doi: 10.1016/0014-2999(81)90588-4. PMID: 6115759.[2]Andorn AC, Carlson MA, Gilkeson RC. Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci. 1988,43(22):1805-12. doi: 10.1016/0024-3205(88)90279-2. PMID: 2904634.[3]Chopin P, Colpaert FC, Marien M. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther. 1999 Feb,288(2):798-804. PMID: 9918591.
