Nitidine chloride是两面针的氯化物，一种植物活性成分，是从广西特有药用植物两面针根部分离得到的生物碱，有抗感染、抗疟疾、抗氧化、抗真菌、抗血管生成以及抗肿瘤等生物活性。Nitidine chloride通过多个靶点通路，发挥抗癌活性，如可抑制促炎性细胞因子如肿瘤坏死因子(TNF-α)、白细胞介素1 β (IL-1 β)和IL-6的产生，抑制NF-кB的转录活性和MAPKs的磷酸化发挥抗炎作用。Nitidine chloride能够抑制多种肿瘤细胞增殖，诱导肿瘤细胞凋亡，抑制STAT3、DNA拓扑异构酶1和2A、ERK 和c-Src/FAK相关信号通路，是潜在的抗肿瘤化合物。Nitidine chloride通过MAPK和NF-kB途径抑制Lps诱导的炎性细胞因子的产生。

参考文献

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冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。