CHPG是一种选择性的mGlu5代谢型谷氨酸受体激动剂（mGluR5激动剂），在BV2小胶质细胞中，CHPG通过TSG-6/NF-κB信号通路减弱SO₂诱导的氧化应激和炎症反应。CHPG还可以通过ERK和Akt信号通路预防体内外的创伤性脑损伤，具有调节脊椎动物大脑的多重效应。

参考文献

[1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.

[2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.

[3]. Besheer J, et al. Stress Hormone Exposure Reduces mGluR5 Expression in the Nucleus Accumbens: Functional Implications for Interoceptive Sensitivity to Alcohol[J]. Neuropsychopharmacology Official Publication of the American College of Neuropsychopharmacology, 2014, 39(10):2376-86.

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