[ 1 ]Intratumoural vaccination via checkpoint degradation-coupled antigen presentation

[ 2 ]A high-throughput selection system for fast-acting covalent protein drugs

[ 3 ]Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control

[ 4 ]The type-I interferon priming signal balances antibacterial and antitumor trained immunity in alveolar macrophages

[ 5 ]De novo engineered disulfide bond supersedes native interchain linkage to enhance TCR pairing and anti-tumor efficacy in T cell therapy

[ 6 ]Rationally designed light-inducible RNA-releasing protein for translational regulation and optogenetic control of gene therapies

[ 7 ]Pangenome and resequencing analyses reveal flowering evolution and genetic control in Cerasus

[ 8 ]Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

[ 9 ]TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

[ 10 ]Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells

[ 11 ]CD4+ Th Cell-Derived Extracellular Vesicles Orchestrate CD8+ T Cells and Eosinophils to Enhance Anti-Tumor Immunity

[ 12 ]A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

[ 13 ]pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

[ 14 ]GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer

[ 15 ]Novel Chitosan Derivatives with Reversible Cationization and Hydrophobicization for Tumor Cytoplasm-Specific Burst Co-delivery of siRNA and Chemotherapeutics

[ 16 ]A dual-function PbrMYBL4-PbrMYB10b/PbrSGRL module regulates anthocyanin and chlorophyll metabolism in pear fruit

[ 17 ]UBE2O primes hepatocytes to restore immune tolerance in autoimmune hepatitis via inhibiting YBX1/IL-6 axis

[ 18 ]Engineering a safe and potent LNP-mRNA delivery system by leveraging the dual activities of α-tocopherol

[ 19 ]Generation and Effect Testing of a SARS-CoV-2 RBD-Targeted Polyclonal Therapeutic Antibody Based on a 2-D Airway Organoid Screening System

[ 20 ]Lactoferrin blocks orthopoxvirus entry via heparan sulphate and regulates host antiviral pathways

[ 21 ]E3 ligase MaNIP1 degradation of NON-YELLOW COLORING1 at high temperature inhibits banana degreening

[ 22 ]Construction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody

[ 23 ]A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol

[ 24 ]Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

[ 25 ]Natural variation in TaRFR1-5B modulates Fusarium head blight resistance via recognition of pTaRIN1-like in wheat

[ 26 ]Transcriptional Activation of ZjPME36 by ZjPosF21 and Repression by ZjWRKY48 Together Regulate Fruit Size in Chinese Jujube

[ 27 ]Apigenin suppresses mycoplasma-induced alveolar macrophages necroptosis via enhancing the methylation of TNF-α promoter by PPARγ-Uhrf1 axis

[ 28 ]Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand 1 Inhibitor as Immune Modulator for Cancer Therapy

[ 29 ]The Cysteine-Rich Secretory Protein TaSCP1-6B Modulates Resistance to Fusarium graminearum in Wheat

[ 30 ]Discovery of New Estrogen-Related Receptor α Agonists via a Combination Strategy Based on Shape Screening and Ensemble Docking

[ 31 ]Novel pituitary actions of GnRH in teleost: The link between reproduction and feeding regulation.

[ 32 ]Overexpression of BnaAGL11, a MADS-Box Transcription Factor, Regulates Leaf Morphogenesis and Senescence in Brassica napus

[ 33 ]The I1NF-YC6 transcription factor of Iris lactea var. chinensis (Fisch.) activates the llCDT1 gene and enhances tolerance to cadmium stress in Arabidopsis thaliana

[ 34 ]A novel mRNA-based therapeutic vaccine elicits robust anti-tumor immunity against HPV-associated malignancies

[ 35 ]Biomechanical stretch-induced CLOCK upregulation in venous smooth muscle cells promotes phenotypic and functional transformation

[ 36 ]The TATA-box binding protein-associated factor ZmTAF11 regulates plant architecture in maize

[ 37 ]Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression

[ 38 ]The miR166d/TaCPK7-D Signaling Module Is a Critical Mediator of Wheat (Triticum aestivum L.) Tolerance to K+ Deficiency

[ 39 ]Adjuvant-Protein Conjugate Vaccine with Built-In TLR7 Agonist on S1 Induces Potent Immunity against SARS-CoV-2 and Variants of Concern

[ 40 ]A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation

[ 41 ]ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages

[ 42 ]Dihydroartemisinin inhibits the activation and proliferation of hepatic stellate cells by regulating miR‑29b‑3p

[ 43 ]A high-efficiency Agrobacterium-mediated transient expression system in the leaves of Artemisia annua L.

[ 44 ]Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase

[ 45 ]SARS-CoV-2 Nsp1 suppresses the canonical NF-κB pathway by promoting ubiquitin-dependent degradation of TAK1 kinase

[ 46 ]DIVARICATA1 Promotes Leaf Degreening and Senescence in Arabidopsis

[ 47 ]Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein

[ 48 ]Integrating yeast chemical genomics and mammalian cell pathway analysis

[ 49 ]tsRNAs sequencing of FFPE tissues reveals i-tRF-Gly-GCC as a biomarker for colorectal cancer

[ 50 ]Phosphoethanolamine cytidylyltransferase 2 exerts an anti-tumor role in clear cell renal cell carcinoma by modulating the hippo/YAP1 signaling pathway in a PPP2R1A-dependent manner

[ 51 ]Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma

[ 52 ]Targeting melanocortin-4 receptor (MC4R) family in goldfish (Carassius auratus) for enhanced growth and optimized lipid distribution

[ 53 ]Cyclophilin A–FoxO1 signaling pathway in endothelial cell apoptosis

[ 54 ]SOX2 promotes hypoxia-induced breast cancer cell migration by inducing NEDD9 expression and subsequent activation of Rac1/HIF-1α signaling

[ 55 ]Origin recognition complex 1 regulates phospholipase Cδ1 to inhibit cell proliferation, migration and epithelial‑mesenchymal transition in lung adenocarcinoma

[ 56 ]Sez6l promotes neuropathic pain via Wnt5a/Ca2+ pathways in dorsal root ganglion

[ 57 ]MiR-485-5p inhibits metastasis and proliferation of osteosarcoma by targeting CX3CL1

[ 58 ]MiR-490-3p inhibited the proliferation and metastasis of esophageal squamous cell carcinoma by targeting HMGA2

[ 59 ]Erianin Suppresses Endometrial Cancer Progression by Regulating the miR-661/BOK Axis