替诺福韦（GS 1278）是一种核苷酸逆转录酶抑制剂，在人类免疫缺陷病毒（HIV）和慢性乙型肝炎（HBV）感染的研究与治疗中具有重要价值。
|
英文别名 (English Synonym) |
Tenofovir |
|
中文名称 (Chinese Name) |
替诺福韦 |
|
靶点 (Target) |
Reverse Transcriptase |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
147127-20-6 |
|
分子式 (Formula) |
C9H14N5O4P |
|
分子量 (Molecular Weight) |
287.21 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Murphy RA, Stafford RM, Petrasovits BA, Boone MA, Valentovic MA. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3):531. doi: 10.3390/ijms18030531. PMID: 28257038; PMCID: PMC5372547.[2]Wahl A, Ho PT, Denton PW, Garrett KL, Hudgens MG, Swartz G, O'Neill C, Veronese F, Kashuba AD, Garcia JV. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098. doi: 10.1038/srep41098. PMID: 28145472; PMCID: PMC5286499.
