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WTAP介导的m6A RNA甲基化在负压伤口治疗下促进糖尿病足溃疡愈合
WTAP‐mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy
Yutong Li, Wenhua Chen, Jianhao Lu, Xiaoyue Lin, Ying Tang, Jiaxu Li, Mingwei Chen
Journal：Journal of Diabetes Investigation
IF：3.6
DOI：10.1111/jdi.70430
PMID：42669871
Published：2026-08-30
research field：RNA表观遗传学分子生物学生物医学工程伤口愈合研究糖尿病并发症
Abstract
NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
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