Intracellular Dual Fluorescent Lightup Bioprobes for Image-Guided Photodynamic Cancer Therapy
Haijie Han, Qiao Jin, Haibo Wang, Wenzhuo Teng, Jina Wu, Hongxin Tong, Tingting Chen, Jian Ji
Journal：Small
IF：8.32
DOI：10.1002/smll.201600950
PMID：27322139
Published：2016-06-20
research field：癌症研究生物医学工程分子成像光动力疗法
Abstract
An intracellular dual fluorescent light-up bioprobe with aggregation-induced emission features and endogenously producing photosensitizer protoporphyrin IX (PpIX) abilities is designed and synthesized. The bioprobe is nonemissive in physiological environment. However, the bioprobe can selectively light up cancer cells with blue fluorescence of tetraphenylene (TPE) and red fluorescence of PpIX, owing to the release of TPE and methyl aminolevulinate after targeted internalization by cancer cells. Moreover, upon endogenous generation and accumulation of PpIX in cancer cells, efficient photodynamic ablation of cancer cells after light irradiation is demonstrated with easy regulation for optimal therapeutic efficacy. The design of such dual fluorescent light-up bioprobes might provide a new opportunity for targeted and image-guided photodynamic cancer therapy.
本文使用的Yeasen产品
