SMC特异性IFN-γ受体敲除通过STAT1-KLF4减轻内膜增生的研究
WITHDRAWN: Smooth muscle cell-specific knockout of interferon gamma (IFN-γ) receptor attenuates intimal hyperplasia via STAT1-KLF4 activation
Journal：LIFE SCIENCES
IF：5.04
DOI：10.1016/j.lfs.2021.119651
PMID：34048810
Published：2021-05-25
research field：分子生物学生物信息学药理学内分泌学中医中药眼科学
Abstract
Intimal hyperplasia is a main contributor to in-stent restenosis. Previous researches have shown that interferon-gamma (IFN-γ), a pleiotropic pro-inflammatory factor, plays a pathological role in intimal hyperplasia. However, the specific role and molecular mechanism of vascular smooth muscle cells (VSMCs)-derived IFN-γ receptor in intimal hyperplasia remains unknown.
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