碳基量子点通过迁移体生物发生增强血小板聚集的机制研究

Abstract

While previous research has primarily focused on nanoparticles larger than 20 nm for promoting migrasome formation, this study shifts the emphasis to nanoparticles smaller than 10 nm. Our findings reveal the significant impact of these sub-10 nm carbon-based quantum dots, specifically carbon quantum dots (CQD), graphene quantum dots (GQD), and graphitic oxide quantum dots (GOQDs), on migrasome formation, mitochondrial integrity, and platelet function. We establish a clear correlation between the application of these nanoparticles and the induction of migrasomes. Furthermore, our results indicate that CQD, GQD, and GOQDs enhance migrasome formation by upregulating phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), cholesterol, and GTP-RhoA. Additionally, these nanoparticles provide mitochondrial protection through a process called mitocytosis and promote increased platelet aggregation. This study represents a pioneering effort to connect various types of nanoscale graphene materials with the dynamic behavior of migrasomes, thereby advancing our understanding of nanoscale materials and their biological implications.