Interleukin 1 alpha (IL-1 alpha ), IL-1 beta, and IL-1 receptor antagonist (IL-1ra) are members of the IL-1 family. IL-1 alpha and IL-1 beta are agonists that bind the functional IL-1 receptor I (IL-1 RI), which then recruits the IL-1 receptor accessory protein (IL-1 R AcP/IL-1 R3) and initiates signal transduction pathways that include the NF-kappa B. JNK/AP-1, and p38 MAP kinase pathways. Both IL-1 alpha and IL-1 beta also bind the non-signaling IL-1 RII that functions as a decoy receptor. IL-1ra is a receptor antagonist that binds both IL-1 RI and II with equal affinity as the IL-1 alpha and beta. Binding of IL-1ra to IL-1 RI does not initiate signal transduction pathways. IL-1 alpha and beta are pro-inflammatory cytokines that play an important role in host defense. The imbalance between IL-1 ( alpha and beta ) and IL-1ra can influence the development of various pathologic conditions associated with chronic inflammation and tissue destruction. Pre-clinical and clinical studies have indicated that IL-1ra may have therapeutic potential for the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia. Rat IL-1ra cDNA encodes a 178 amino acid (aa) residues secreted protein with a 26 aa signal peptide. Although intracellular isoforms of human IL-1ra that are transcribed from the same gene using different promotors have been described, analogous rat isoforms have not been reported. Rat IL-1ra shares 89% and 73% aa sequence homology with mouse and human IL-1ra, respectively. Secreted IL-1ra has been shown to be expressed by monocytes, macrophages, neutrophils, fibroblasts and hepatocytes.
高纯度、高活性、低内毒素、高批间一致性
-25 ~ -15℃保存,收到货之后有效期1年。 复溶后,无菌条件下,2~8℃保存,7天有效期。复溶后, 无菌条件下,-85 ~ -65℃保存,3个月有效期。
[90102ES]Recombinant Human IL-1RA Protein 重组人白介素-1RA
[90141ES]Recombinant Mouse IL-1RA 重组小鼠白介素-1RA
[90182ES]Recombinant Porcine IL-1RA 重组猪白介素-1受体拮抗剂
[90185ES]Recombinant Equine IL-1RA 重组马白介素-1RA
[94211ES]Human IL-1RL1/ST2 Protein, His Tag 重组人 IL-1RL1/ST2
[94157ES]Biotinylated Human IL-1R3/IL-1 RAcP Protein, His-Avi Tag
[93844ES]Recombinant Biotinylated Human IL-1Rrp2/IL-1R6 Protein,His-Avi Tag
[94158ES]Recombinant Human IL-1R3/IL-1 RAcP Protein,His-Avi Tag