分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
重组蛋白
细胞因子
抗体
高通量测序建库
病原检测UCF系列
生物医药
工具酶
抑制剂激活剂与常用试剂
仪器
耗材
Recombinant Mouse I-TAC/CXCL11 (Mouse I-TAC/CXCL11) 重组小鼠I-TAC/CXCL11
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产品介绍

CXCL11 also known as I-TAC is belonging to the CXC chemokine family. CXCL11, together with MIG and IP-10, constitute a subset of chemokines that are ligands for CXCR3, a chemokine receptor that is primarily expressed on activated Th1 cells and NK cells. Mouse CXCL11 also shares 36% and 29% aa sequence identity with mouse IP-10 (Crg-2) and mouse MIG, respectively. CXCL11 binds CXCR3 with a higher affinity than CXCL10, suggesting that CXCL11 has the potential to restrain inflammatory autoimmunity. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes.CXCL11 is not only a major effector for T cell chemotaxis in the pathophysiology of neuroinflammatory disorders, but also plays a crucial role in migration of activating T cells during IFN-dominated immune responses.

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产品特色

高纯度、高活性、低内毒素、高批间一致性

存储条件

-25 ~ -15℃保存,收到货之后有效期1年。 复溶后,无菌条件下,2~8℃保存,7天有效期。复溶后, 无菌条件下,-85 ~ -65℃保存,3个月有效期。

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