Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus . While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses.

高活性、高纯度、低内毒素、高批间一致性

                                        SDS-PAGE

Human IL-31 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

                                                   HPLC

The purity of Human IL-31 is greater than 95% as determined by SEC-HPLC.

                                                   ELISA Data

Immobilized Human IL-31, His Tag at 5μg/ml (100μl/Well) on the plate. Dose response curve for Human IL-31 RA, hFc Tag with the EC50 of 1.53μg/ml determined by ELISA.

                                                 SPR Data

Human IL-31, His Tag immobilized on CM5 Chip can bind Human IL-31 RA, His Tag with an affinity constant of 125.61 nM as determined in SPR assay.

-25~-15℃保存，收到货之日起，有效期1年。复溶后， -85~-65℃保存，3个月有效期。避免反复冻融。