Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of PMEL17 / GP100 in Human melanoma lysates using Melanocyte Protein PMEL antibody.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.