产品简介
GDNF是一种二硫键连接的同源二聚体神经营养因子,是多巴胺和运动神经元的有效生长因子,在结构上与Artemin、Neurturin和Persephin相关。GDNF通过多组分受体系统发出信号,该系统由RET和四种GFRα(α1-α4)受体之一组成。GDNF特异性地促进多巴胺的摄取和存活,以及中脑神经元的形态分化。帕金森病小鼠模型中,GDNF可以改善运动迟缓、僵硬和姿势不稳定等情况。
本品以液体形式提供,具有高纯度、高活性和低内毒素特点。
性能参数
蛋白别名(Synonyms) |
GDNF,glial cell derived neurotrophic factor,glial cell line derived neurotrophic factor,glial cell line-derived neurotrophic factor,HFB1-GDNF,HGDNF,HSCR3 |
种属(Species) |
Human |
表达系统(Source) |
HEK293 |
表达序列(Sequence) |
Arg109-Ile211 |
Accession |
P39905 |
标签(Tag) |
No Tag |
分子量(Molecular Weight) |
The protein has a predicted MW of 11.6 KDa |
内毒素(Endotoxin) |
Less than 0.01 EU per μg by the LAL method. |
纯度(Purity) |
> 95%, determined by SDS-PAGE |
活性(Activity) |
Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The EC50 for this effect is 2-12 ng/mL in the presence of Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog # 714-GR). |
制剂(Formulation) |
Dissolved in sterile PBS buffer. |
外观(Appearance) |
Liquid |
储存条件
-85~-65℃保存,收到货之后有效期1年。
避免反复冻融,打开小瓶前先离心。建议等分分装为一次实验使用量,分装后,-80℃冻存。
注意事项
Ver. CN20250314