中枢性性早熟患儿iPSC细胞系(FDCHi006-A)的建立与鉴定
Generation of an induced pluripotent stem cell line (FDCHi006-A) from a 7-year-old girl with central precocious puberty
Teng Fan, Jingwei He, Yonghong Wang, Jian Yu, Wen Sun
Journal：Stem Cell Research
IF：2.02
DOI：10.1016/j.scr.2021.102542
PMID：34619645
Published：2021-09-28
research field：肿瘤学分子生物学癌症研究药理学
Abstract
Central precocious puberty (CPP) refers to a pediatric endocrine disease in which boys have secondary sexual characteristics before the age of 9 and girls before the age of 8. In this study, we generated an induced pluripotent stem cell line FDCHi006-A from the Peripheral blood cell of a typical central precocious patient who was only 7 years old. This iPSC line showed full pluripotency, normal karyotype and differentiation capacity without integrating vectors. It provides a useful model to study the underlying molecular mechanisms of CPP.
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