The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway
Tang Chun, Wang Xuehui, Ji Changle, Zheng Wenfang, Yu Yunhe, Deng Xiaochong, Zhou Xiqian, Fang Lin
Journal：Frontiers in Oncology
IF：6.24
DOI：10.3389/fonc.2021.645682
PMID：33912460
Published：2021-04-12
research field：
Abstract
In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis via Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy.
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