SA4503激活Sigma-1受体通过减轻线粒体功能障碍和内质网应激介导的凋亡保护复苏后脑损伤

Abstract

Cardiac arrest followed by resuscitation can induce brain injury, and currently, there are no effective treatments for brain damage after cardiopulmonary resuscitation (CPR), necessitating the exploration of additional therapeutic strategies and prevention approaches. This study aimed to investigate the mechanism of action by which SA4503 activates the Sigma-1 receptor (Sig-1R) to protect against ischemic brain injury in both in vitro and in vivo models. The goal of this study was to provide theoretical support for SA4503 as a potential therapeutic agent and promote clinical intervention research for post-resuscitation brain injury following CPR.