Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

推荐稀释比 WB:1/500-1/1000; IHC:P:1/100-1/200; ICC/IF:1/100-1/200

Western blot analysis of MLKL in HUVEC，RAW264.7 lysates using MLKL antibody.

Immunohistochemistry analysis of paraffin-embedded Human colon using MLKL antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of MLKL in 3T3, SW480, Ramos and Hela lysates using MLKL antibody.

Western blot analysis of MLKL in HUVEC lysates using MLKL antibody

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.