Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of Telomerase Reverse Transcriptase in Human mucinous type of soft sarcoma and Human fetal liver lysates using Telomerase Reverse Transcriptase antibody

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Telomerase Reverse Transcriptase antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.