SN38 is the active metabolite of the chemotherapy drug irinotecan (Camptosar). It is  a topoisomerase I inhibitor, prevents the enzyme from properly resealing the DNA strands after they have been unwound, which leads to the accumulation of DNA damage.

SDS-PAGE

SEC-HPLC

ELISA Data

-25~-15℃保存

Q：请问Anti-SN-38 Mouse mAb是只结合SN38还是也结合伊立替康？

A：只能特异性结合SN-38，而不能结合其前体药物伊立替康。