南美超级胎牛血清999尝鲜特惠
骨髓间充质干细胞移植通过Hippo信号通路减轻小鼠脑出血后脑损伤
Bone marrow mesenchymal stem cells transplantation alleviates brain injury after intracerebral hemorrhage in mice through the Hippo signaling pathway
Xiao Chen, Can-Xin Xu, Huaibin Liang, Zhiyu Xi, Jiaji Pan, Yong Yang, Qingfang Sun, Guoyuan Yang, Yuhao Sun, Liuguan Bian
Journal：Aging-US
IF：4.83
DOI：10.18632/aging.103025
PMID：32271159
Published：2020-04-09
research field：转化医学药理学细胞生物学免疫学呼吸病学
Abstract
Intracerebral hemorrhage (ICH) is a common acute nervous system disease with high mortality and severe disability. Mesenchymal stem cells (MSCs) have been reported to promote neurogenesis and to alleviate side effects in areas of brain injury areas. The Hippo pathway regulates diverse cellular processes, including cell survival, proliferation, differentiation, and organ size. Here, we found that transplantation of bone marrow MSCs (BM-MSCs) into the brains of mice could alleviate ICH-mediated injury and protect astrocytes from apoptosis by regulating mammalian sterile 20-like kinase (MST)1 and Yes-associated protein (YAP). Knocking down of MST1 by si-RNA triggered YAP nuclear translocation. We further demonstrated that astrocytes undergo astroglial-mesenchymal phenotype switching and become capable of proliferating after BM-MSC transplantation via the Hippo signaling pathway. Together, our identification of the Hippo pathway in mediating the beneficial effects of BM-MSCs may provide a novel therapeutic target in the treatment and management of ICH.
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