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重组人Tie-2蛋白(hFc标签) Recombinant Human Tie-2 Protein,hFc Tag(96722ES)

Recombinant Human Tie-2 Protein,hFc Tag
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产品应用
产品介绍
TIE-2, or TEK, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells . Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region . Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence
产品性质
产品特色
高活性、高纯度、低内毒素、高批间一致性
应用案例
ELISA Data: Immobilized Angiopoietin-2(275-496)His Tag,Human at 5.0μg/mL (100μL/well) can bind Tie-2 Fc Chimera,Human with EC50 of 1.00-2.09μg/ml. SPR Data:Protein A Chip captured Tie-2 Fc Chimera, Human can bind Angiopoietin-2(275-496) His Tag, Human with an affinity constant of 0.75μM as determined in SPR assay.
存储条件
-25 ~ -15℃保存,收到货之后有效期1年。复溶后,无菌条件下,2~8℃保存,7天有效期。复溶后, 无菌条件下,-85 ~ -65℃保存,3个月有效期。
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