STK3 Rabbit pAb
产品介绍
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
产品性质
产品特色
推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IP:1/20
应用案例
Western blot analysis of STK3 in HeLa lysates using STK3 antibody.
Immunohistochemistry analysis of paraffin-embedded Human kidney using STK3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
存储条件
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
COA
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