Participate in a variety of cellular functions, including histone deacetylation, gene silencing, chromosomal stability, and aging. SIRT2, a human homolog of the yeast SIR2, functions as transcriptional silencing mediator at mating-type loci, telomeres and ribosomal gene clusters. SIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G(2)/M transition of the cell cycle.

Western

Western blot analysis of SIRT2 in mouse brain, U87-MG lysates using SIRT2 antibody.

Western

Western blot analysis of SIRT2 in rat Brain lysates using SIRT2 antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human colon cancer using SIRT2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.