Circ_0008777通过PC4/miR-185-3p/c-Myc轴促进头颈部鳞状细胞癌进展

Circ_0008777 promotes head and neck squamous cell carcinoma progression by elevating c-Myc expression levels via interacting with PC4 and miR-185–3p

Weixing Liu, Zhiyuan Wang, Pei Li, Yue Liu, Jia Chen, Zhi Shi, Hui Liu, Jin Ye

Journal：Translational Oncology

IF：4.9

DOI：10.1016/j.tranon.2026.102856

PMID：

Published：2026-06-16

research field：肿瘤学分子生物学RNA生物学头颈肿瘤学

Abstract

Highlights • Circ_0008777 is upregulated in HNSCC and correlates with poor prognosis.• Circ_0008777 binds PC4 to enhance c-Myc transcription in HNSCC cells.• Circ_0008777 acts as a sponge for miR-185–3p, relieving c-Myc repression.• Circ_0008777 promotes HNSCC progression via c-Myc upregulation in vitro and in vivo.• Targeting circ_0008777 may offer a novel therapeutic strategy for HNSCC.

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