FcRn is an unusual Fc receptor, the biological importance of which is only beginning to be fully appreciated. In addition to its critical role in the transfer of maternal IgG to the fetus or neonate, FcRn is the homeostatic receptor responsible for extending the serum half-life of IgG in adults. The exact site(s) of IgG protection from degradation has not been delineated in vivo, but both endothelial cells and bone-marrow-derived cells can extend the serum persistence of IgG. FcRn is also expressed in many other tissues in the adult animal, including barrier sites such as the blood–brain interface, the glomerular filter in the kidneys and the intestinal epithelium. FcRn expression at these sites merits further study with the goals of modulating specific IgG transport to promote host defence or to control immune-complex deposition.

高纯度、高活性、低内毒素、高批间一致性

        SDS-PAGE

1μg (R: reducing conditions, N: non-reducing conditions).

       SPR  Data

Anti-His antibody Immobilized on CM5 Chip captured Cynomolgus  FcRn His Tag Protein  can bind Anti-HER2 Monoclonal Antibody(Trastuzumab)  with an affinity constant of 0.94μM as determined in SPR assay.

-25 ~ -15℃保存，收到货之后有效期1年。
复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。复溶后， 无菌条件下，2~ 8℃保存，1周有效期。