The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

推荐稀释比 WB:1/500-1/1000;IF:1/50-1/200;FC:1/50-1/100;ELISA:1/10000

Immunocytochemistry analysis of BMP4 in Hela cells using BMP4 antibody(red),and DAPI(blue). Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.