Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Western

Western blot analysis of FDPS in CHO-K1 lysates using FDPS antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using FDPS antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.