Foretinib是多靶点酪氨酸激酶抑制剂，作用于Met、KDR、Tie-2和VEGFR3的IC₅₀值分别为0.4 nM、0.86 nM、1.1 nM和2.8 nM，具有抗肿瘤活性。

参考文献

[1] Qian F, Engst S, Yamaguchi K, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 2009 Oct 15;69(20):8009-16. doi: 10.1158/0008-5472.CAN-08-4889(IF:8.378).

[2] Kataoka Y, Mukohara T, Tomioka H, et al. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs. 2012 Aug;30(4):1352-60. doi: 10.1007/s10637-011-9699-0(IF:2.663).

-25~-15℃保存，有效期3年。