Begacestat (GSI-953, GSI953)是可口服的γ -secretase选择性噻吩磺酰胺抑制剂，抑制阻断APP的Aβ方向剪切，在表达人重组APP的细胞中，减少Aβ40和Aβ42，有潜力用于阿尔兹海默症的研究。

参考文献

1.Mayer SC, et al. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem. 2008 Dec 11;51(23):7348-51.

2.Martone RL, et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608.

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