BlasticidinS是一种来自Streptomycesgriseochromogenes的核苷类抗生素，通过干扰核糖体中肽键的形成来特异性地抑制原核和真核生物的蛋白质合成。BlasticidinS用于筛选携带有bsr或BSD耐受基因的转染细胞。杀稻瘟菌素具有快速而强效的作用模式，很低的抗生素浓度便能导致细胞迅速死亡。
Cat#60218ES10、60218ES50、60218ES60均以液体形式提供，浓度为10 mg/mL（in HEPES缓冲液，pH 7.5）。
Cat#60218ES80为粉末形式提供，使用时可用无菌水或者缓冲液配制成5-10 mg/mL的储存液。
相关产品推荐：
| 产品名称 | 产品编号 |
| Carbenicillin, Disodium Salt 羧苄青霉素钠 | 60202ES |
| Ampicillin, Sodium Salt 氨苄青霉素钠 | 60203ES |
| Doxycycline hyclate 盐酸强力霉素 | 60204ES |
| Chloramphenicol, USP Grade 氯霉素，USP级 | 60205ES |
| Kanamycin Sulfate 硫酸卡那霉素 | 60206ES |
| Puromycin Dihydrochloride嘌呤霉素盐酸盐 | 60210ES |
| Tetracyclin HCl 四环素盐酸盐（USP） | 60212ES |
| Vancomycin Hydrochloride 盐酸万古霉素 | 60213ES |
| Gentamycin Sulfate Salt 硫酸庆大霉素 | 60214ES |
| Spectinomycin Hydrochloride 盐酸壮观霉素 | 60215ES |
| 盐酸博莱霉素 | 60216ES |
| Phleomycin (20mg/ml in solution) 腐草霉素 | 60217ES |
| Blasticidin S 杀稻瘟菌素S （灭瘟素） | 60218ES |
| Nystatin 制真菌素 | 60219ES |
| G418 Sulfate (Geneticin) 遗传霉素 | 60220ES |
| Hygromycin B 潮霉素B | 60225ES |
| Erythromycin 红霉素 | 60228ES |
| Timentin 特美汀 | 60230ES |
| Aureobasidin A （AbA）金担子素A | 60231ES |
| Polymyxin B Sulfate 多粘菌素B硫酸盐 | 60242ES |
-25~-15℃保存。粉末有效期3年，液体有效期2年，避免反复冻融。
Q：与 G418 有何区别？
A：Blasticidin S 用于筛选携带有 bsr 或BSD 耐受基因的转染细胞，G418 用于筛选哺乳动物细胞中含抗性基因neo 和植物细胞中含有nptII 基因。
Q:60218ES80配置方法？
A：使用1M的HEPES或者1×PBS配成浓度为10 mg/mL的母液。
Q: 60218的液体形式是无菌的吗？
A: 该产品经过过滤处理，液体形式产品为无菌产品。
[1] Xiao J, Xiong Y, Yang LT, et al. POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. Protein Cell. 2021;12(4):279-296. doi:10.1007/s13238-020-00753-3(IF:10.164)
[2] Wei W, Li Y, Wang C, et al. Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells [published online ahead of print, 2022 Jun 1]. Pharmacol Res. 2022;182:106285. doi:10.1016/j.phrs.2022.106285(IF:7.658)
[3] Qian F, Hu Q, Tian Y, et al. ING4 suppresses hepatocellular carcinoma via a NF-κB/miR-155/FOXO3a signaling axis. Int J Biol Sci. 2019;15(2):369-385. Published 2019 Jan 1. doi:10.7150/ijbs.28422(IF:6.582)
[4] Li Q, Yu D, Yu Z, et al. TIPE3 promotes non-small cell lung cancer progression via the protein kinase B/extracellular signal-regulated kinase 1/2-glycogen synthase kinase 3β-β-catenin/Snail axis. Transl Lung Cancer Res. 2021;10(2):936-954. doi:10.21037/tlcr-21-147(IF:6.498)
[5] Li Y, Fu Y, Hu X, et al. The HBx-CTTN interaction promotes cell proliferation and migration of hepatocellular carcinoma via CREB1. Cell Death Dis. 2019;10(6):405. Published 2019 May 28. doi:10.1038/s41419-019-1650-x(IF:5.959)
[6] Li X, Wu A, Han C, et al. Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells. Aging (Albany NY). 2019;11(20):9167-9187. doi:10.18632/aging.102390(IF:5.515)
[7] Yue C, Jin H, Zhang X, et al. Aucubin prevents steroid-induced osteoblast apoptosis by enhancing autophagy via AMPK activation. J Cell Mol Med. 2021;25(21):10175-10184. doi:10.1111/jcmm.16954(IF:5.310)
[8] Wu J, Lv Q, He J, et al. MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes. Cell Commun Signal. 2014;12:66. Published 2014 Oct 11. doi:10.1186/s12964-014-0066-6(IF:4.672)
[9] Huang H, Zou X, Zhong L, et al. CRISPR/dCas9-mediated activation of multiple endogenous target genes directly converts human foreskin fibroblasts into Leydig-like cells. J Cell Mol Med. 2019;23(9):6072-6084. doi:10.1111/jcmm.14470(IF:4.658)
[10] Huang H, Zhong L, Zhou J, et al. Leydig-like cells derived from reprogrammed human foreskin fibroblasts by CRISPR/dCas9 increase the level of serum testosterone in castrated male rats. J Cell Mol Med. 2020;24(7):3971-3981. doi:10.1111/jcmm.15018(IF:4.486)
[11] Wang X, Du A, Yu G, Deng Z, He X. Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S. Front Microbiol. 2017;8:1565. Published 2017 Aug 22. doi:10.3389/fmicb.2017.01565(IF:4.076)
[12] Zhao Y, Ye X, Chen R, et al. Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling. Oncol Rep. 2020;44(3):959-972. doi:10.3892/or.2020.7672(IF:3.906)
[13] Zhang M, Liu X, Wang Q, et al. NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death. FEBS Lett. 2017;591(21):3670-3681. doi:10.1002/1873-3468.12861(IF:3.623)
[14] Wang XF, Tian Q, Qin WB, et al. Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line. J Reprod Dev. 2020;66(3):223-230. doi:10.1262/jrd.2019-139(IF:1.735)
